Despite the technical details to be solved or improved, the emergent availability of lignin sources and the know-how developed in researcher centers creates an opportunity to evaluate the profitability of including an oxidation process in the chemical platform of a biorefinery. The aldehydes productivity of lignins with different characteristics (due to the specie, delignification process and further processing or special treatments) is an emergent topic of research. In the perspective of biomass-based industries and biorefinery sustainability, this is very welcome information. Improving the treatment methods to preserve the lignin fraction with higher productivity on aldehydes (for example, by membrane separation before the reaction step) could also provide important technological advances for the application of lignin. Vanillin and syringaldehyde are just the beginning of a long road running to the sustainable future of commodities from renewable sources.