Most corn ethanol dry-grind plants in the Midwest usually keep an inventory of corn for 10 days of production (Mukunda 2007). Corn is normally delivered to the plant by trucks from within a 60-mile radius. Just like in elevators, delivery trucks queue in line to be sampled, weighed, and their cargo dumped. The rule of thumb is that for every 1MMGY of plant capacity, a truck of 1000bu (25,500 kg) of grain is delivered daily. Thus, for a 40, 60, and 100MMGY, an average of 40, 60, and 100 trucks will deliver corn to the plant daily. With the current capacities in fuel ethanol plants, there has been no report about challenges or difficulties in receiving grain. In fact, some of the ethanol plants have contracted their grain procurement to the major grain logistics operations that have many years of experience and infrastructure handling and shipping grain. If these plants were to be retrofitted to process cellulosic feedstocks, how would their current layout designed for granular feedstocks perform? This could be one of the major challenges faced by existing biorefineries using grain feedstocks that are looking to change to cellulosics in the nearby future. In the next section, a framework for designing and mapping the layout of a biorefinery or preprocessing facility using lignocellulosic feedstock will be discussed.