Significant activity of clostridia toward consuming lignocellulosic biomass uncovers the space of cheaper feedstock for ABE fermentation. However, efficient techniques for removing the inhibitors, generated during hydrolysis of lignocel — lulosic materials, can make it a more effective feedstock. From the economic point of view, the integrated system of hydrolysis, fermentation, and recovery process also opens vital ways to reduce the capital and operational cost of butanol syn­thesis. More developments in the recovery techniques such as gas stripping will boost up to this integrated fermentation process for improving the productivity. Additionally, completion of genome sequencing of two clostridial species pro­vided the crucial opportunity to genetic engineers to engineer the genome of butanol-producing species to improve its capability toward high yield and butanol resistance.