Table 5 provides a preliminary comparison between organic solvent extraction and SCCO2 extraction for lipid extraction from microalgae. A more thorough under­standing of mass transfer mechanism and kinetic parameters involved in lipid extraction from microalgae is needed for an extensive comparison. Large use of toxic solvents and energy-intensive solvent-lipid separation represent the main dis­advantages with commercial use of organic solvent extraction, while expensive fluid compression and high installation cost of an extraction pressure vessel remain the primary obstacles for large-scale SCCO2 extraction [50]. The theoretical advan­tages of SCCO2 extraction, such as tunable selectivity for specific lipid fractions and enhanced kinetics due to the fluid intermediate physicochemical properties, still need to be verified for microalgal lipid extraction.