Owing to the attractiveness of D. salina for biotechnology, there is a renewed interest in engineering this organism. Publications have reported the genetic transformation of D. salina by both microparticle bombardment and electroporation (Geng et al., 2003; Tan et al., 2005). Some of the most impressive progress in the field has come from the Xue group at Zhengzhou University in China. With research covering optimization of transformation techniques, gene characterization, and enhanced gene expressing utilizing matrix attachment regions, their work provides important information and an exemplary research path to follow toward genetic engineering of D. salina (Wang et al., 2009; Lu et al., 2009; Jia et al., 2009a; Feng et al., 2009; Wang et al., 2007; Jia et al., 2009b; Liu et al., 2005; Jiang et al., 2003). The down-regulation of specific genes using RNAi in D. salina has also been reported (Jia et al., 2009a; Sun et al., 2008). These advances, however, are not readily reproducible and represent solitary accomplishments with an alga that has otherwise been difficult to transform.