The process of framing an evaluation requires close interaction between the analysts and the sponsors to specify the scope, particularly the system elements (facilities, processes, materials) and the range and definition of threats. The institutional context in which safeguards and other international controls would be implemented (national and international safeguards requirements and regulatory guidance, etc.) must also be specified in sufficient detail.

The process allows for evaluation to be performed at many levels, depending on the sponsor’s needs. From pre-conceptual design to a fully operational facility, the evaluation can and must become progressively more detailed. Timeframe can also dictate the depth of analysis; quick and coarse evaluations may be needed when answers are required within weeks or months and, for some problems, potentially even sooner. Such shortcuts, however, entail a higher degree of uncertainty in the results.