Electrospun Cellulose Fibers

Although cellulose is extensively available and has been used as fibers in native and regenerated form, it is difficult to dissolve cellulose in electrospinnable solvents and therefore there are limited reports on producing electrospun cellulose fibers. Ionic liquids that have been used to dissolve cellulose and produce regenerated fibers have also been used to develop electrospun fibers [08Xu]. Cotton linters with a degree of polymerization of 1,600 were dissolved using 1-allyl-3-methylimi — dazolium chloride (AMIMCl) and dimethylsulfoxide (DMSO) by stirring at 80 °C for 1 h. Fibers with diameters ranging from 100 to 800 nm were obtained using solution concentrations from 3 to 5 %. Addition of DMSO decreased the surface tension, entanglement density, and viscosity of the solution leading to the formation of nanofibers. Cellulose in the electrospun fibers had low crystallinity

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Fig. 58.13 Confocal images showing the morphologies of the 3T3 fibroblasts at different locations and depths on the fibronectin coated on derivatized hyaluronic acid [06Ji] (a) is the morphology of the cells on FN-adsorbed cover slips; (b) is below the surface of FN-adsorbed HA-DTPH scaffold; (c) on the surface of FN-adsorbed HA-DTPH scaffolds and (d) is 32 pm below the surface of the FN-adsorbed DTPH scaffold

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Fig. 58.14 Image of the hyaluronic acid/collagen blend scaffold obtained after electrospinning. From Kim et al. [08Kim]. Reproduced with permission from Elsevier

and was considered to be in the cellulose II form. Cellulose was dissolved in [Bmim][Cl] and heparin was added for potential use of the fibers for construction of artificial blood vessels [06Vis]. Although limited information was presented on the properties of the fibers, it was reported that heparin retained the anticoagulant property even after high voltage electrospinning.

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Fig. 58.15 Actual structure and morphology of the hyaluronic/collagen blend scaffold after washing and salt leaching. From Kim et al. [08Kim]. (a) digital image of the scaffold; (b) surface morphology; (c and d) SEM images at two different magnification. Reproduced with permission from Elsevier