A hydrodynamic fluidic separation system based on fluidic shear as the culture stream passes through a spiral pattern in the fluidic device has been developed at the Palo Alto Research Center. This system is a spiral channel through which the culture is passed; drag from the channel walls exerts forces that separate particles from the suspending solution such that separated, concentrated, and dilute streams come out at the end of the separator. The device can be run continuously, requires no filters, is generally large enough to prevent fouling, and requires no additional materials for the separation. They have demonstrated a benefit to the use of flocculants with small algae in this system. Such a system would also have minimal or no fouling due to the large size of the fluid channels. This device has been used with Scenedesmus dimorphus with chitosan as a flocculant and provided a 42-fold increase in concentration. With Arthrospira platensis and no flocculant, the device provided 5.8-fold concentration on one pass and 18.8-fold on two passes through the concentrator providing a 97.3 % harvesting efficiency (Hsieh et al. 2012; Volkel et al. 2011). There are currently no reports of use of this technology at large scale with algae.