Our knowledge about cell wall biosynthesis and biodegradation has steadily increased in the past decades, although there is still a long way to go to fully understand these extremely complex processes. So far our knowledge is at best fragmented and characterized genes are often from various organisms and dispersed in the literature. Therefore, dedicated, centralized and frequently updated databases of bioenergy-related genes are crucial to guide the development of transgenic biofuel crops and the annotation of newly sequenced metagenomes/genomes to look for novel enzymes. Like other biology research areas, bioenergy research has also been benefiting from bioinformatics. Table 6.2 provides a list of bioinformatics databases and web — based resources developed specifically for bioenergy — related enzymes as well as some general bioinformatics web resources that are valuable for bioenergy research. Here we offer a summary of a few selected resources that are particularly useful.